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Chemical structures of cisplatin and phenanthriplatin. Cisplatin is a bifunctional platinum(II) complex whose anticancer activity is primarily related to its ability to intercalate and distort DNA leading to activation of DNA repair and cell death mechanisms. Phenanthriplatin is a heterocyclic-ligated monofunctional platinum(II) complex that is proposed to cause cancer cell death via blockage of gene transcription while evading DNA repair mechanisms.
