Table 2.
Phenanthriplatin and cisplatin modulate gene regulation in A549 cells. Top 10 up- and downregulated DEGs for A549 cisplatin versus A549 control. DEG data analysis: (p ≤ 0.05; q ≤ 0.05; log2FC ≥ 0; FPKM ≥ 1 in ≥ 3 samples; average FPKM ≥ 1 minimum count: 10).
| Gene (↑) | Log2FC | p-Value | q-Value | Gene (↓) | Log2FC | p-Value | q-Value |
|---|---|---|---|---|---|---|---|
| ATF3 | 2.757 | 1.880 × 10−74 | 4.441 × 10−71 | MCM5 | −0.482 | 7.133 × 10−11 | 9.723 × 10−9 |
| GDF15 | 1.962 | 2.950 × 10−91 | 1.393 × 10−87 | SLIT3 | −0.530 | 6.219 × 10−13 | 1.101 × 10−10 |
| CDKN1A | 1.852 | 2.829 × 10−142 | 4.010 × 10−138 | TRAPPC9 | −0.565 | 2.361 × 10−21 | 1.014 × 10−18 |
| FDXR | 1.728 | 2.276 × 10−111 | 1.613 × 10−107 | SAPCD2 | −0.686 | 1.617 × 10−12 | 2.730 × 10−10 |
| BTG2 | 1.639 | 2.434 × 10−45 | 2.875 × 10−42 | KCNMA1 | −0.710 | 2.770 × 10−12 | 4.620 × 10−10 |
| MDM2 | 1.490 | 2.982 × 10−62 | 4.227 × 10−59 | MSRA | −0.769 | 4.236 × 10−10 | 5.177 × 10−8 |
| SESN2 | 1.467 | 8.864 × 10−28 | 5.815 × 10−25 | MCM6 | −0.782 | 1.516 × 10−17 | 4.478 × 10−15 |
| GADD45A | 1.458 | 8.776 × 10−78 | 2.488 × 10−74 | GPC6 | −0.940 | 3.773 × 10−25 | 2.057 × 10−22 |
| FAS | 1.384 | 3.439 × 10−35 | 3.482 × 10−32 | CDH4 | −1.940 | 1.156 × 10−31 | 9.432 × 10−29 |
| DDB2 | 1.350 | 4.346 × 10−88 | 1.540 × 10−84 | LSAMP | −3.677 | 3.272 × 10−16 | 8.434 × 10−14 |