Table 3.

Phenanthriplatin and cisplatin modulate gene regulation in IMR90 cells. Top 10 up- and downregulated DEGs for IMR90 phenanthriplatin versus IMR90 control. DEG data analysis: (p ≤ 0.05; q ≤ 0.05; log₂FC ≥ 0; FPKM ≥ 1 in ≥ 3 samples; average FPKM ≥ 1 minimum count: 10).

Gene (↑)	Log2FC	p-Value	q-Value	Gene (↓)	Log2FC	p-Value	q-Value
ATF3	5.364	≤0.0001	≤0.0001	HMGA2	−3.439	≤0.0001	≤0.0001
SAT1	4.094	≤0.0001	≤0.0001	ASAP1	−3.543	≤0.0001	≤0.0001
GDF15	3.657	≤0.0001	≤0.0001	GSK3B	−3.549	≤0.0001	≤0.0001
GADD45A	3.433	≤0.0001	≤0.0001	LBH	−3.571	≤0.0001	≤0.0001
NPTX1	2.941	7.459 × 10−307	2.830 × 10−304	NRG1	−3.680	≤0.0001	≤0.0001
PCNA	2.344	≤0.0001	≤0.0001	IGF2BP2	−4.246	≤0.0001	≤0.0001
PEG10	2.312	≤0.0001	≤0.0001	COL1A1	−4.330	≤0.0001	≤0.0001
TM4SF1	2.103	≤0.0001	≤0.0001	SLC38A2	−4.409	≤0.0001	≤0.0001
TFPI2	2.007	≤0.0001	≤0.0001	ZMIZ1	−4.422	≤0.0001	≤0.0001
TNFRSF10D	2.006	≤0.0001	≤0.0001	SMURF2	−4.866	≤0.0001	≤0.0001