Table 5.

Comparative analysis of gene regulation between phenanthriplatin and cisplatin treatments in A549 and IMR90 cells. Top 10 up-and downregulated DEGs for A549 phenanthriplatin versus A549 cisplatin. DEG data analysis: (p ≤ 0.05; q ≤ 0.05; log₂FC ≥ 0; FPKM ≥ 1 in ≥ 3 samples; average FPKM ≥ 1 minimum count: 10).

Gene (↑)	Log2FC	p-Value	q-Value	Gene (↓)	Log2FC	p-Value	q-Value
TFF1	4.503	≤0.0001	≤0.0001	PFKFB3	−4.165	≤0.0001	≤0.0001
RBP4	3.360	≤0.0001	≤0.0001	DAPK1	−4.210	≤0.0001	≤0.0001
CST1	2.984	≤0.0001	≤0.0001	NR3C1	−4.246	≤0.0001	≤0.0001
SNHG14	2.741	≤0.0001	≤0.0001	RAI1	−4.316	≤0.0001	≤0.0001
TFPI2	2.740	≤0.0001	≤0.0001	PDE4D	−4.425	≤0.0001	≤0.0001
SERF2	2.733	≤0.0001	≤0.0001	ZNF609	−4.451	≤0.0001	≤0.0001
S100A6	2.722	≤0.0001	≤0.0001	MDM2	−4.538	≤0.0001	≤0.0001
S100A4	2.675	≤0.0001	≤0.0001	SIN3A	−4.629	≤0.0001	≤0.0001
FSTL3	2.661	≤0.0001	≤0.0001	B4GALT5	−4.724	≤0.0001	≤0.0001
COX8A	2.654	≤0.0001	≤0.0001	TNFRSF1A	−5.596	≤0.0001	≤0.0001