Table 6.

Comparative analysis of gene regulation between phenanthriplatin and cisplatin treatments in A549 and IMR90 cells. Top 10 up-and downregulated DEGs for IMR90 phenanthriplatin versus IMR90 cisplatin. DEG data analysis: (p ≤ 0.05; q ≤ 0.05; log₂FC ≥ 0; FPKM ≥ 1 in ≥ 3 samples; average FPKM ≥ 1 minimum count: 10).

Gene (↑)	Log2FC	p-Value	q-Value	Gene (↓)	Log2FC	p-Value	q-Value
THSD4	3.658	≤0.0001	≤0.0001	PUM1	−2.792	≤0.0001	≤0.0001
NPTX1	3.163	≤0.0001	≤0.0001	TRAM2	−2.797	≤0.0001	≤0.0001
P4HA3	2.809	≤0.0001	≤0.0001	CDC42EP3	−2.833	≤0.0001	≤0.0001
CEMIP	2.668	≤0.0001	≤0.0001	PSME4	−2.860	≤0.0001	≤0.0001
GADD45A	2.616	≤0.0001	≤0.0001	FOXP1	−3.229	2.013 × 10−283	8.117 × 10−281
SERPINE2	2.045	≤0.0001	≤0.0001	GSK3B	−3.275	4.903 × 10−290	2.314 × 10−287
DCN	1.906	≤0.0001	≤0.0001	SMURF2	−3.359	≤0.0001	≤0.0001
COL4A2	1.875	≤0.0001	≤0.0001	NRG1	−3.561	≤0.0001	≤0.0001
TFPI2	1.692	≤0.0001	≤0.0001	IGF2BP2	−3.569	4.865 × 10−272	1.711 × 10−269
PEG10	1.689	≤0.0001	≤0.0001	SLC38A2	−4.173	≤0.0001	≤0.0001