ObR	leptin receptor
GBM	glioblastoma multiforme
HGG	high-grade glioma
LGG	low-grade glioma
T2DM	type 2 diabetes mellitus
TMZ	temozolomide (TMZ)
POMC	pro-opiomelanocortin
NPY/AgRP	neuropeptide Y/agouti-related protein
ARC	arcuate nucleus
BBB	blood-brain-barrier
CSF	cerebrospinal fluid
JAKs	Janus kinase family
STATs	signal transducers and activators of transcription
SOCS3	suppressor of cytokine signaling-3
ERK	extracellular signal regulated kinase
MAPK	mitogen activated protein kinase
mTOR	mammalian target of Rapamycin
SH-2	Src- homology domain 2
SH2B1	domain containing protein 1B
(IRS)	insulin receptor substrate
(PI3K)	phosphoinositide-3-kinase
WAT	white adipose tissue
RT-PCR	reverse transcriptase-polymerase chain reaction
PDGF-BB	platelet-derived growth factor-BB
PECAM-1	platelet endothelial cell adhesion molecule-1
IL	interleukins
TNF-α	tumor necrosis factor
VEGF	vascular endothelial growth factor
HGF	hepatocyte growth factor
MABS	monoclonal antibodies
CAR	chimeric antigen receptor
D-2HG-D2	hydroxy-glutamate
CQ	chloroquine
IDH	isocitrate dehydrogenase
BDNF	brain-derived neurotrophic factor
MFRMN	metformin hydrochloride
MFLOQ	mefloquine
MEMTN	memantine
PI3K-(IRS)	phosphoinositide-3-kinase
sPLA2-IIa	phospholipase A2-IIa)
AMPK	adenosine monophosphate associated protein kinase
Rb	retinoblastoma protein
CCDN1	cyclin D1
BIRC5	survivin
HSP90A	heat shock protein
HIF1A	hypoxia inducible factor
MMP-13	matrix metalloproteinase-13
UPR	unfolded protein response
GRP78	chaperone molecule; 78 kDa glucose regulated protein
DDR	DNS damage response
NSCLC	non-small cell lung cancer
RCT	randomized controlled trial
EE	environmental enrichment
OS	overall survival
PFS	progression-free survival
RT	radiotherapy
EORTC-QLQ	European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Brain Tumor Module (EORTC-QLQ-BN20).