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. 2020 Dec 9;9(12):885. doi: 10.3390/antibiotics9120885

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Time-kill curves for pentamidine at 1/2×MIC in combination with antibiotics against the clinical strains Pa29, Pa206 and Pa249. (a) Pa29, (b) Pa206 and (c) Pa249; GC: growth control, filled circles; pentamidine (PNT, 1/2xMIC), filled squares; antibiotics alone (IMP: imipenem, CAX: ceftazidime, CIP: ciprofloxacin; ATM: aztreonam, 1xMIC), filled triangles; PNT (1/2xMIC) + antibiotics (1xMIC), filled inverted triangles. Dotted line: indicates when and how long a compound alone or a combination has bactericidal activity.