Table 3.
Synergistic and bactericidal activities of pentamidine in combination with antibiotics against the seven Pseudomonas aeruginosa clinical strains.
Clinical Strain | PNT + AMK | PNT + GEN | PNT + TOB | PNT + IMP | PNT + MEM | PNT + ATM | PNT + CAZ | PNT + CIP | PNT + LFX | PNT + COL |
---|---|---|---|---|---|---|---|---|---|---|
Pa29 | - | - | - | B (2–24) S (24) |
B (2–24) S (24) |
- | B (4–24) | - | - | - |
Pa194 | B (4–24) S (8–24) |
B (2–8) S (8–24) |
B (2–24) S (24) |
B (2–24) S (24) |
B (2–24) S (24) |
- | B (2–24) S (24) |
B (4–24) S (8–24) |
B (2–24) | - |
Pa206 | - | - | - | B (2–24) | B (8–24) S (24) |
- | - | B (2–24) | B (2–24) | - |
Pa215 | B (2–24) S (8–24) |
B (2–24) S (8–24) |
- | B (2–8) S (8) |
B (2–24) | - | B (2–8) | B (2–24) S (2–24) |
B (2–24) S (8–24) |
B (2–8) |
Pa223 | B (24) S (24) |
- | - | B (2–24) S (8–24) |
B (2–24) S (24) |
B (4–24) S (24) |
B (4–24) S (24) |
B (4–24) S (24) |
B (2–24) | - |
Pa249 | - | - | - | B (2–24) S (2–24) |
B (2–24) S (24) |
B (8–24) | - | B (2–24) S (2–24) |
B (2–24) S (2–24) |
- |
Pa302 | - | - | - | B (4–24) S (8) |
- | - | - | - | B (8–24) S (24) |
- |
PNT: pentamidine; AMK: amikacin; GEN: gentamicin; TOB: tobramycin; IMP, imipenem; MEM: meropenem; ATM: aztreonam; CAZ: ceftazidime; CIP: ciprofloxacin; LFX: levofloxacin; COL: Colistin. B: bactericidal; S, synergistic; (): time frame in hours of the in vitro activity found.