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. 2020 Dec 9;12(12):3694. doi: 10.3390/cancers12123694

Figure 1.

Figure 1

A diagrammatic representation of immune suppressive mechanisms within primary uveal melanoma and the ocular micro-environment that would inhibit NK cell function and cytotoxicity. APP: Anti-apoptotic protein; HLA: Human Leukocyte Antigen; IDO: Indoleamine-2,3-dioxygenase; IFN: Interferon; KIR: Killer Immunoglobulin-like Receptor (inhibitory receptor on NK cell that binds HLA on tumor cells); MIF: Macrophage Inhibitory Factor; TIGIT: T cell immunoreceptor with Ig and ITIM domain); TRAIL: Tumor Necrosis Factor (TNF)-related apoptosis inducing ligand on NK cells that binds receptors on tumor cells. (Figure created with BioRender.com).