Table 2.

Relevant NK cell activating, and inhibitory receptors and their corresponding ligands expressed in uveal melanoma.

Common Human NK Inhibitory Receptors (iKIRs) and Their Corresponding Ligands	Common Human NK Activating Receptors and Their Corresponding Ligands	NK Ligands Expressed in Uveal Melanoma and Their Corresponding NK Receptors
KIR2DL1 (HLA-C2) KIR2DL2–3 (HLA-C1) KIR3DL1 (HLA-HLA-Bw4) KIR3DL2 (HLA-A*03, A*011) CD94/NKG2A/B (HLA-E) [110]	NKG2D (MIC A/B, ULBP) DNAM-1 (CD112, CD155) NCRs: NKp46, NKp44, NKp30 (Heparan Sulfate Glycosaminoglycans and others) [111,112,113,114]	HLA-A/B/C (iKIRs) HLA-E (NKG2A) ULBP1–3 (NKG2D) MIC-A/B (NKG2D) CD155, CD112 (DNAM-1) [103,116]

DNAM-1 (DNAX Accessory Molecule-1); HLA (Human Leukocyte Antigen); KIR (Killer Immunoglobulin-like Receptor; MIC-A/B (Major histocompatibility complex [MHC] class I chain-related protein A/B); NCR (Natural Cytotoxicity Receptor); NKG2A/D (Natural-killer group 2, member A/D); ULBP1–3 (UL16 binding protein 1–3).