Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 10;21(24):9412. doi: 10.3390/ijms21249412

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Inhibition of the IL-24/STAT3 axis during AHR activation enhances the upregulation of FLG and LOR expression in keratinocytes. (1) Tapinarof upregulates FLG and LOR expression in an AHR-dependent manner. (2) Tapinarof produces IL-24, an activator of the JAK/STAT3 axis that negatively regulates FLG and LOR expression, via AHR activation. (3) Blockade of the IL-24-STAT3 axis during AHR activation using JAK inhibitor supports the upregulation of FLG and LOR expression induced by tapinarof treatment.