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. 2020 Dec 9;8(12):1951. doi: 10.3390/microorganisms8121951

Figure 2.

Figure 2

Cartoon showing the complex protein folding landscape. Nascent, unfolded proteins travel down an energy gradient seeking the lowest energy conformation. Proteins can sample various energy minima on this journey including folding intermediates and the native fold state. However, every protein has the potential to reach other energy minima, including unfolded or partially ordered aggregates. In addition, all proteins can adopt the true lowest energy state, the amyloid fibril. Adapted from Jahn and Radford [50].