Figure 4.

The insoluble amyloid forms of Sup35p and Cb-Rho allow the creation of protein variants better suited to survive in sudden environmental fluctuations. In yeast, the loss of an active translation termination factor Sup35p leads to a stop codon read-through, giving rise to new phenotypes. In bacteria, the same result is accomplished through the loss of the transcriptional terminator factor Rho and, thereby, a decrease in transcriptional fidelity.