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. 2020 Dec 9;12(12):1194. doi: 10.3390/pharmaceutics12121194

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Optimization of SNEDDSs (a) ternary diagrams from [49], (b) Box–Benkhen design from [58]. Drug: polypeptide-k, Factors Oleoyl polyoxyl-6 glycerides (oil, X1), Tween^® 80 (surfactant, X2), diethylene glycol monoethyl ether (cosolvent, X3); responses: percentage drug loading (Y3), (c) central composite design from [53]. Drug: Bosentan, Factors: Capmul^® and Labrasol^® (surfactants, X1), MCM (oil, X2), and PEG 600 (cosolvent, X3); responses: percentage drug release in 15 min (Y4), (d) simplex lattice design from [61]. Drug: pentagamavunon-0, Factors: oil (oleic acid, X1), surfactants (Tween^® 20 and Labrasol^®, X2), cosolvent (PEG 400, X3); response: particle size (Y1) (e) D-optimal design from [56]. Drug: cardamom essential oil, Factors: coconut oil (X1), Tween^® 80 (X2) and PEG 400 (X3); response: transmittance percentage (Y2).