Table 4.
Pharmacokinetics data reporting enhanced bio-availability from Self-Emulsifying Drug Delivery Systems (SEDDS) in human subjects.
| Drug | Components | In Vivo Observation | References |
|---|---|---|---|
| Vitamin E | Palm oil, Tween® 80, Span® 80 | 3-fold higher oral bio-availability from SEDDSs. | [223] |
| Cyclosporin | Corn oil glycerides, Cremophor® RH40, PG, DL-α-tocopherol and ethanol | AUC0–t and Cmax increased 1.18 and 1.17-fold, respectively from SEDDSs. | [224] |
| Tocotrienols | Tocomin, Soybean oil Tween® 80 Labrasol® |
2 to 3-fold higher oral bio-availability from SEDDSs. | [82] |
| Saquinavir (Fortovase®) | Medium-chain mono- and di-glycerides | Increased oral bio-availability up to 331% from Fortovase® compared to Invirase®. | [198] |
| Simvastatin | Labrafil®, Tween® 80, Transcutol® HP | 1.55 and 1.5 increased in Cmax and AUC0–t, respectively from SNEDDSs. | [225] |
| Vitamin K | Vitamin K, Labrasol®, Transcutol® HP | Enhancement in vitamin K relative bio-availability from SNEDDSs. | [222] |