Table 1.
Summary of Protocols from Studies Discussing the Use of Microneedling for Scar Treatment
| Treatment Protocol | Combination Therapies | |||
|---|---|---|---|---|
| Microneedling (n=36) | Number of passes | 4–10 | Procedural | Platelet-rich plasma (PRP; n=6) Subcision (n=3) Incobotulinum toxin (n=1) Polymethylmethacrylate-collagen gel (n=1) |
| Clinical endpoint | Uniform pinpoint bleeding | Topicals or peels | Glycolic acid peel (n=3) Trichloroacetic acid peel (n=2) Amniotic fluid-derived mesenchymal stem cell, topical (n=1) Hyaluronic acid (n=1) Jessner’s solution peel (n=1) Vitamin A and C, topical (n=1) |
|
| Needle depth | 1.5–3.0 mm | Systemic therapy | Systemic isotretinoin (n=1) | |
| 1–12 treatment sessions, every 1–8 weeks | ||||
| Microneedle patch (n=2) | Continuously for 30 days (n=1), changed every 2–3 days for 4–6 weeks (n=1) | |||
| Fractional radiofrequency microneedling (insulated and non-insulated, multiple and single-needle heads, n=20) | Number of passes | 2–8 | Injectable/procedural | Fractional carbon dioxide (CO2; n=2) Fractional 1550 nm erbium-glass (Er:glass; n=1) Hyaluronic acid (n=1) Subcision (n=1) |
| Clinical endpoint | Wheal-like papules/plaques | Topicals | Poly-lactic acid (PLA; n=1) | |
| Needle depth | 0.8–3.5 mm | Systemic therapy | Systemic isotretinoin (n=1) | |
| Energy | 6.82–70 W, 40–82 mJ | |||
| Duration | 50–400 ms | |||
| Total pulses | 250–500 | |||
| 1–6 treatment sessions, every 4–12 weeks | ||||