Figure 7.

BOILED-Egg plot. Points located in the BOILED-Egg’s yolk (yellow) represent the molecules predicted to passively permeate through the blood–brain barrier, whereas those in the egg white are relative to the molecules predicted to be passively absorbed by the gastrointestinal tract; the blue dots indicate the molecules that were expected to be effluated from the central nervous system (CNS) by P-glycoprotein, whereas the red ones represent the molecules predicted not to be effluated from the CNS by P-glycoprotein.