Table 2.
List of the metabolites that were significantly altered after intravenous administration of Prostanit in rabbits. p-Values were calculated by comparison of the areas under the curve (AUC) of the analyzed metabolites in tested and vehicle control groups using parametric or non-parametric a/b tests (Student t-test and Mann–Whitney test, respectively).
| Name of the Metabolite | Class | Calculated p-Value |
|---|---|---|
| Androsterone | Steroids | 7.73 × 10−7 |
| Testosterone | Steroids | 4.15 × 10−4 |
| Corticosterone | Steroids | 1.08 × 10−10 |
| Cortisol | Steroids | 5.55 × 10−11 |
| GABA | Amino acid | 0.035 |
| Aminoisobutyric acid | Amino acid | 3.49 × 10−6 |
| Adenosine | Purines | 2.71 × 10−4 |
| Guanosine | Purines | 0.031 |
| Glycine | Amino acid | 4.67 × 10−−4 |
| Alanine | Amino acid | 0.0191 |
| Proline | Amino acid | 1.49 × 10−5 |
| 4-Hydroxyproline | Amino acid | 7.44 × 10−8 |
| Isoleucine | Amino acid | 3.86 × 10−3 |
| Aspartate | Amino acid | 5.55 × 10−11 |
| Phenylalanine | Amino acid | 6.57 × 10−4 |
| Carnosine | Amino acid | 4.037 × 10−7 |