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. 2020 Dec 8;10(12):1646. doi: 10.3390/biom10121646

Figure 5.

Figure 5

Figure 5

LncRNA-DANCR is a competitive inhibitor of miR-216a. (A) Potential binding position of DANCR MRE and miR-216a; (B) (top) schematic of MCP-MS2 immunoprecipitation assay; (bottom) MCP–MS2 immunoprecipitation assay using A549 DANCR KD cells transfected with MS2-DANCR compared to MS2-control cells (n = 3, t test, *** p < 0.001); (C) (top) schematic of luciferase-DANCR reporter assay; (bottom) 293T cells cotransfected with luciferase-DANCR reporter + miR-216a expression plasmid compared to luciferase-DANCR reporter + vector control cells (n = 3, t test, *** p < 0.001); (D) fold change of miR-216a expression in NSCLC cell lines compared to lung epithelial cell line HBE2 (n = 3, t test, *** p < 0.001, **** p < 0.0001).