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. 2020 Dec 10;21(24):9401. doi: 10.3390/ijms21249401

Figure 2.

Figure 2

Target gene specificity for HIF1α(P-A)2, HIF2α(P-A)2 and the HIF(P-A)2 (N2/C1), HIF(P-A)2 (N1/C2) chimeric versions in WT8 cells. (A) Relative BNIP3, PGM1 and CAIX gene expression in control WT8 cells and those expressing the HIF1α(P-A)2, HIF2α(P-A)2 and the HIF(P-A)2 (N2/C1) or HIF(P-A)2 (N1/C2) chimeric constructs; (B) relative PHD3, OCT-4, NDRG1, TFGA, GLUT1, CCND1 and SLC7A5 expression in control WT8 cells (n = 6), and those expressing the HIF1α(P-A)2 (n = 6), HIF2α(P-A)2 (n = 6) and the HIF(P-A)2 (N2/C1) (n = 6) or HIF(P-A)2 (N1/C2) (n = 4) chimeric constructs. Data are shown as mean ± SEM. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. * p < 0.05, ** p < 0.01, and *** p < 0.001. Significance with control group is indicated.