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Target gene selectivity for HIF1α or HIF2α in the kidney of Vhl−/− mice. Relative Epo, Phd3, Slc7a5, CaIX, Glut1 and Pgm1 expression in the kidney of Vhl−/− mice (n = 6), Vhl−/−Hif1a−/− mice (n = 3), Vhl−/−Hif2a−/− mice (n = 5) and the corresponding controls (n = 8–10). Data are shown as mean ± SEM. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. * p < 0.05, ** p < 0.01, and *** p < 0.001.
