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. 2020 Dec 13;12(12):3752. doi: 10.3390/cancers12123752
ECM: extracellular matrix
PMN: pre-metastatic niche
BMDC: bone marrow-derived cells
MDSC: myeloid-derived suppressor cells
TAM: tumor-associated macrophage
EV: extracellular vesicles
EMT: epithelial-to-mesenchymal transition
CAF: cancer associated fibroblast
HSC: hematopoietic stem cell
BBB: blood–brain barrier
IL-6: interleukin 6
IL-1β: interleukin-1β
CXCL12/SDF-1 α: stromal cell-derived factor 1
IL-8: interleukin 8
VEGF: vascular endothelial growth factor
G-CSF: granulocyte-colony stimulating factor
MIF: macrophage migration inhibitory factor
TIMP-1: tissue inhibitor of metalloproteinases 1
GM-CSF: granulocyte–macrophage colony-stimulating factor
SAA: serum amyloid A
TGF-β: transforming growth factor beta
HIF-1: hypoxia-inducible factor 1
CCL2: CC-chemokine ligand 2
CCL5: chemokine ligand 5
CXCL1: C–X–C motif ligand 1
JAK: Janus kinase
STAT3: signal transducer and activator of transcription 3
AKT: protein kinase B
MAPK: mitogen-activated protein kinase
IDO: indoleamine 2,3-dioxygenase
PD-L1: programmed death ligand 1