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. Author manuscript; available in PMC: 2020 Dec 26.
Published in final edited form as: Cell Rep. 2020 Dec 8;33(10):108486. doi: 10.1016/j.celrep.2020.108486

Figure 1. Uniporter Architecture and Regulation.

Figure 1.

(A) A cartoon illustrating EMRE- and MICU-dependent regulation of the uniporter. Only 2 copies of MCU and EMRE in the MCU-EMRE tetramer are illustrated to show the Ca2+ pathway.

(B) Structure of the human MCU-EMRE subcomplex. The 3 MCU-EMRE contact sites, the JML (green, bottom right), and the JML surrounding areas (blue, bottom right) are highlighted. The second coiled-coil (CC2) in MCU is broken into halves, CC2a and CC2b. The MCU subunit in cyan shows a large fenestration between its 2 TM helices.

CC, coiled-coil; NTD, N-terminal domain; TMH, transmembrane helices.

See also Figure S1.