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(A) Ca2+ transport mediated by hMCU chimeras containing JML sequence from D. discoideum (Dd), N. fischeri (Nf), or D. melanogaster (Dm) MCU homologs. Chimeric proteins were expressed in MCU-KO (black) or ME-KO (red) cells.
(B) The activity of various hMCU (Hs)-C. elegans MCU (Ce) chimeras measured in the presence (black) of absence (red) of hEMRE.
Data are presented as means ± SEMs. Hs, WT hMCU control.
