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Taking advantage of oncogenic addiction in cancer with synthetic dosage lethality. (A) Myc produces target genes Aurora kinases A and B and CDK1, which help stabilize Myc and promote the cell cycle. MYC is commonly amplified in cancer and cells remain viable. (B) In MYC-overexpressing cancers, inhibiting CDK1 or Aurora kinases leads to cell cycle arrest and synthetic dosage lethality.
