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. 2020 Dec 8;9(12):1248. doi: 10.3390/antiox9121248

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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DPI treatment induces senescence of HCT116 cells. (A) HCT116 cells were treated with 0.5 µM DPI for 3 days and SA-β-gal activity was analyzed; (B) the level of protein markers of senescence—p53, p-p53 and p21, and apoptosis—PARP cleavage (indicated by arrowhead) and γH2AX—was estimated at different time points after DPI (0.5 µM) treatment. (C) BrdU incorporation analysis was performed in HCT116 p53+/+ cells. The percentage of cells that were able to incorporate BrdU within 24 h of culture is presented on the graph (mean ± SD, four experiments); *** p ≤ 0.001.