Figure 1.

Cancers in which specific connexin functions have been described to be pro-tumorigenic. Schematic showing examples of the cancer types in which pro-tumorigenic properties have been attributed to a specific connexin function, whether gap junction intercellular communication (GJIC), connexin hemichannels, or a non-junctional function. Bold red text indicates strong evidence from many cancer types tying the connexin function to the corresponding cancer hallmark, with red text indicating a less robust link and black text indicating emerging evidence. Where mechanistic studies in cancer cells are not available, certain non-transformed cell populations are indicated. References for the indicated cancers are provided in the text. Figure illustrations generated using BioRender.com.