Table 2.
Vessel densities (VDs) in the deep and superficial layers after ripasudil or bimatoprost instillation.
| Eye Drop and Side | Median (25th Percentile, 75th Percentile) | p Value ab | p Value ac | ||
|---|---|---|---|---|---|
| At Baseline | At 15 min | At 2 h | |||
| Ripasudil group Right eye |
|||||
| Deep VD, % | 13.11% (11.52%, 15.92%) | 19.91% (14.82%, 24.07%) | 14.80% (12.03%, 19.98%) | <0.001 | 0.009 |
| Superficial VD, % | 28.46% (25.08%, 35.43%) | 37.29% (33.2%, 40.90%) | 31.64% (27.42%, 36.75%) | <0.001 | 0.015 |
| Ripasudil group Left eye |
|||||
| Deep VD, % | 14.28% (11.83%, 16.45%) | 13.49% (10.61%, 18.16%) | 13.52% (10.41%, 16.94%) | 0.33 | 0.85 |
| Superficial VD, % | 29.45% (25.04%, 33.64%) | 27.27% (23.16%, 33.69%) | 29.56% (26.78%, 33.90%) | 0.093 | 0.91 |
| Bimatoprost group Right eye |
|||||
| Deep VD, % | 24.21% (16.96%, 27.43%) | 19.34% (15.19%, 25.06%) | 22.07% (17.50%, 26.16%) | 0.037 | 0.48 |
| Superficial VD, % | 42.64% (39.49%, 46.84%) | 39.53% (35.23%, 47.19%) | 48.19% (45.02%, 53.95%) | 0.010 | 0.011 |
| Bimatoprost group Left eye |
|||||
| Deep VD, % | 20.55% (17.01%, 25.87%) | 23.41% (16.24%, 31.80%) | 22.40% (18.68%, 30.80%) | 0.18 | 0.10 |
| Superficial VD, % | 42.73% (38.25%, 46.25%) | 42.28% (37.09%, 48.51%) | 46.46% (39.54%, 49.09%) | 0.85 | 0.067 |
a Calculated using the Wilcoxon signed-rank test. Values that are statistically significant are shown in bold, after setting the limit for false-positive error to 0.0125 after Bonferroni correction for multiple analyses. b Comparison between findings at baseline and at 15 min. c Comparison between findings at baseline and at 2 h.