Table 3.
Factors associated with the percent changes in intraocular pressure (IOP).
| Ripasudil | Percent IOP Change at 15 min | Percent IOP Change at 2 h | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate Analysis | Multivariable Analysis a | Univariate Analysis | Multivariable Analysis a | |||||||||
| B | β | p | B | β | p | B | β | p | B | β | p | |
| Use of eye drop | −8.677 | −0.657 | <0.001 | −8.191 | −0.620 | <0.001 | −13.034 | −0.521 | 0.001 | −11.822 | −0.473 | 0.001 |
| Baseline IOP | −0.419 | −0.163 | 0.32 | - | - | - | −0.018 | −0.004 | 0.98 | - | - | - |
| Baseline deep VD | 0.366 | 0.34 | 0.032 | 0.267 | 0.248 | 0.044 | 0.808 | 0.396 | 0.011 | 0.665 | 0.326 | 0.018 |
| Baseline superficial VD | 0.064 | 0.077 | 0.64 | - | - | - | 0.486 | 0.308 | 0.053 | 0.72 | ||
| Change in deep VD at 15 min | −0.031 | −0.36 | 0.023 | 0.70 | −0.025 | −0.155 | 0.34 | - | - | - | ||
| Change in deep VD at 2 h | −0.014 | −0.086 | 0.60 | - | - | - | 0.033 | 0.106 | 0.51 | - | - | - |
| Change in superficial VD at 15 min | −0.094 | −0.468 | 0.002 | 0.61 | −0.151 | −0.398 | 0.011 | 0.61 | ||||
| Change in superficial VD at 2 h | −0.053 | −0.236 | 0.14 | - | - | - | −0.109 | −0.254 | 0.11 | - | - | - |
| Bimatoprost | Percent IOP Change at 15 min | Percent IOP Change at 2 h | ||||||||||
| Univariate Analysis | Multivariable Analysis a | Univariate Analysis | Multivariable Analysis a | |||||||||
| B | β | p | B | β | p | B | β | p | B | β | p | |
| Use of eye drop | −4.274 | −0.092 | 0.57 | 0.070 | −6.715 | −0.12 | 0.46 | −9.587 | − 0.171 | 0.004 | ||
| Baseline IOP | −9.363 | −0.878 | < 0 .001 | −9.363 | −0.878 | <0.001 | −11.844 | −0.927 | <0.001 | −11.964 | −0.936 | < 0 .001 |
| Baseline deep VD | −1.03 | −0.304 | 0.056 | 0.74 | −1.416 | −0.349 | 0.027 | 0.89 | ||||
| Baseline superficial VD | 0.167 | 0.054 | 0.74 | - | - | - | 0.628 | 0.170 | 0.29 | - | - | - |
| Change in deep VD at 15 min | 0.014 | 0.024 | 0.89 | - | - | - | −0.013 | −0.019 | 0.91 | - | - | - |
| Change in deep VD at 2 h | 0.063 | 0.086 | 0.60 | - | - | - | 0.054 | 0.062 | 0.70 | - | - | - |
| Change in superficial VD at 15 min | 0.265 | 0.194 | 0.23 | - | - | - | 0.283 | 0.173 | 0.29 | - | - | - |
| Change in superficial VD at 2 h | −0.185 | −0.110 | 0.50 | - | - | - | −0.187 | −0.093 | 0.57 | - | - | - |
Abbreviations: VD = vessel density; Β = unstandardized regression coefficient; β = standardized regression coefficient. Values that are statistically significant are shown in bold. a Stepwise regression analysis for all variables with p < 0.1 in a univariable regression model with use of eyedrops.