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. 2020 Dec 11;9(12):2662. doi: 10.3390/cells9122662

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Summary: MADM enabled labeling of sparse clones in dorsolateral cortices of +/+ and F/+ mice reveals switch to gliogenesis around E15 followed by seeding of glia without involvement of glia-restricted clones from early neurogenic period. Allelic Egfr dosage analysis using MADM with a conditional allele for Egfr revealed that the background cells and their genotype (Egfr-heterozygous) influence Egfr-null (green) and wild type (WT, red) MADM siblings. Comparison of cortical MADM progeny in +/+ and F/+ cortices exposed a dosage response in glial populations whereby WT MADM cells expand to compensate for loss of glia in their MADM green siblings. Neurogenic clones exhibit symmetric and deterministic patterns of expansion, whereas clonal expansion during gliogenesis is highly asymmetric and stochastic.