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. 2020 Dec 9;12(12):3699. doi: 10.3390/cancers12123699

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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p53 network in primary samples. (a) Force directed layout showing the single cell expression level (arcsinh transformed dual counts) of CD34 (581), p53 (DO-7), ac-p53 [K382] (REA529), p53^mut (Y5), Ki67 (B56) and p21^(CIP1/WAF1) (12D1). (b) Heatmap showing the relative expression level of intracellular signaling proteins in selected cell populations. Clusters are color-coded corresponding to the color of the cluster name in Figure 3a. Color scale indicates expression level (arcsinh ratio) relative to the CD34⁺CD38^dimp53⁺ population in patient AML017 (top row).