Figure 2.

Adipose tissue EVs protein cargo and its alteration on the course of obesity. A summary of AT specific proteins described so far in the literature including those proteins present in EVs shed by normal/healthy adipocytes (A); those present or elevated with insulin resistance, lipid hypertrophied adipocytes (B); and those characteristic of subcutaneous and visceral human obese AT (C). Proteins in bold were found elevated compared to control healthy adipocytes, or compared to those released by adipose tissue of lean individuals. AT: adipose tissue; IR: insulin resistance; AEBP1: adipocyte enhancer-binding protein 1; HSL: hormone sensitive-lipase; FAS: fatty acid synthase; MVP: major vault protein; MIF: macrophage migration inhibitory factor; AACS: acetoacetyl-CoA synthetase; LPS: lipoprotein lipase; FABP: fatty acid binding protein; G3PDH: glyceraldehyde 3-phosphate dehydrogenase; CAVN1: caveolae associated protein 1; MMP: matrix metalloproteinase; ITH3: inter-α-trypsin inhibitor heavy chain H3; GDF15: growth differentiation factor 15; IL: interleukin; MUC18: cell surface glycoprotein; AHNAK: neuroblast differentiation-associated protein; TGFBI: transforming growth factor-beta-induced protein ig-h3.