2D	Two-dimensional
3D	Three-dimensional
5-LOX	Arachidonate 5-lipoxygenase
AEM	Animal Enclosure Module
Apaf-1	Apoptosis protease activating factor-1
APO-1	Apoptosis antigen 1
BAECs	Bovine aortic endothelial cells
DISC	Death-inducing signalling complex
DLR	Deutsches Zentrum für Luft- und Raumfahrt
ESA	European Space Agency
FADD	Fas-associated protein with a death domain
HDBR	Head-down bed rest
HS	Hindlimb suspension
HOB	Human osteoblastic
HUVEC	human umbilical vein endothelial cells
HZE	High (H) atomic number (Z) and energy (E)
IL	Interleukin
ISS	International Space Station
LET	Linear energy transfer
MCS	Multicellular spheroid(s)
MDA-MB231	M.D. Anderson-Metastasis Breast cancer cell line
MDS	Mice Drawer System
mRNA	messenger RNA
miRNA	microRNA
mTOR	Mammalian target of rapamycin
NASA	National Aeronautics and Space Administration
NOX2	Nicotinamide adenine dinucleotide phosphate oxidase 2
NK	Natural killer
NF-κB	Nuclear factor kappa B
OPN	Osteopontin
PARP	Poly (ADP-ribose) polymerase
PFA	Paraformaldehyde
PBLs	Peripheral blood lymphocytes
qPCR	Quantitative polymerase chain reaction
RPM	Random positioning machine
RANKL	Receptor Activator of NF-κB Ligand
RCCS-HARV	Rotational Cell Culture System-High Aspect Ratio Vessel
ROS	Reactive oxygen species
RWV	Rotating-wall vessels
RIP	Receptor-interacting protein
RPE	Retinal pigment epithelial
RPM	Random positioning machine
SRF	Serum Response Factor
SOD	Superoxide dismutase
SODD	Silencer of death domain
STS	Space transportation system
TNBC	Triple-negative breast cancer
TUNEL	Terminal deoxynucleotidyl transferase-mediated nick end-labeling
TNF	Tumor necrosis factor
TRADD	TNFR-associated protein with a death domain
TS	Tubular structure
WHO	World Health Organization
XIAP	X-linked inhibitor of apoptosis