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Effect of in vitro PRHD stimulation of macrophages (RAW 264.7), osteosarcoma (UMR-106), and stem (ASCs) cells proliferative activity as a function of concentration (a) after 24 h and (b) after 48 h of exposure. Panel (c) shows morphology changes of macrophages (RAW 264.7), osteosarcoma-derived cells (UMR-106), and stem cells (ASCs) after 48 h in vitro exposure to PRHD nanoparticles and control.
