. 2020 Dec 14;12(12):3755. doi: 10.3390/cancers12123755

Table 2.

Detection of i(12p) or additional copies of chromosome 12 without i(12p) by fluorescence in situ hybridization (FISH) in primary tumors and SMNs.

Case No.	Primary Testicular Tumor	Age at Initial Diagnosis	Primary Treatment	Age at SMN	Time to SMN (Yrs.)	SMN Histology	Metastatic Tumor	% i(12p) FISH Positive	# i(12p) Copies
1	Seminoma *	51	BEP	57	6.5	Unclassified sarcoma	RP	56%	1–2
2	Seminoma	31	XRT	54	22.0	Colorectal	Liver	68%	1
3	Seminoma	28	XRT, BEP, HDC + SCT	34	5.9	LMS	Gluteus	64%	1–2
4	Seminoma	53	BEP	56	3.1	Urothelial	Bladder	39%	1
5	Nonseminoma	39	BEP	39	0.4	Pancreatic	Pancreas	63%	1–3
Case No.	Primary Histology	Age at Initial Diagnosis	Primary Treatment	Age at SMN	Time to SMN (Yrs.)	SMN Histology	Site of SMN	% Extra Copies Chromosome 12	# i(12p) Copies
6	Seminoma	33	XRT	51	18.0	LMS	RP	73%	0
7	Seminoma	51	XRT	59	7.6	Rectal (adenocarcinoma)	Rectum	55%	0
8	Seminoma	58	XRT	71	13.3	Colorectal	Cecum	36%	0
9	Seminoma	57	XRT	65	8.5	Lung (adenocarcinoma)	Lung	72%	0
10	Seminoma	29	XRT	59	24.6	Melanoma	Axillary lymph node	83%	0
10	Nonseminoma	44	BEP	59	24.6	Melanoma	Axillary lymph node	83%	0
11	Seminoma	22	XRT	58	9.6	LMS	RP	72%	0
12	Nonseminoma	28	CISCA/VB	45	36.3	LMS	RP	74%	0
13	Seminoma	53	XRT	58	44.8	Colorectal	Lung	83%	0
14	Seminoma	62		65	5.2	Lung (squamous)	Lung	61%	0
15	Seminoma	27	XRT	81	3.0	Urothelial	Bladder	66%	0
16	NA	20	XRT + VB	57	53.6	Adrenal Cortical Carcinoma	Adrenal	89%	0
17	Seminoma	31	XRT	61	36.6	Bladder	Bladder	82%	0
18	Seminoma	29	CTX/carboplatin	49	29.9	Urothelial	Renal pelvis	51%	0
19	Seminoma	47	XRT	65	20.3	Renal cell carcinoma	Kidney	57%	0
20	Seminoma	29	PVB	54	19.4	Urothelial	Bladder	91%	0

BEP: bleomycin, etoposide, cisplatin. XRT: radiation therapy. HDC + SCT: high-dose chemotherapy + stem-cell transplantation. CEB: carboplatin, etoposide, bleomycin. PVB: cisplatin, vinblastine, bleomycin. CISCA: cyclophosphamide, doxorubicin, cisplatin. VB: vinblastine, bleomycin. CTX: cyclophosphamide. LMS: leiomyosarcoma. RP: retroperitoneum. * Diagnosed by biopsy of retroperitoneal lymph node. Pathology of primary tumor not available.