Figure 1.

CKD patients of the Biomarker Discovery (A,B) and the Predictive Model (C,D) cohorts were classified as progressive (red) or non-progressive (grey/black) based on a composite outcome of a ≥30% decline in eGFR from baseline, initiation of dialysis, or kidney transplantation. This definition distinctly classified CKD patients as progressive and non-progressive. Progressive patients demonstrated a larger maximum eGFR decrease (%) from baseline compared to non-progressive patients (A,C). Progressive patients of the Biomarker Discovery cohort demonstrated a negative trajectory for eGFR percentage change from the baseline, which differed significantly (p < 0.0001) from non-progressive patients who demonstrated a positive trajectory (C). Both progressive and non-progressive patients of the Predictive Model cohort demonstrated negative trajectories; however, these were significantly different from each other with progressive patients demonstrating a more negative trajectory (D). Abbreviations: Chronic kidney disease (CKD), estimated glomerular filtration rate (eGFR).