Table 1.

Updated Chompret Criteria for Germline TP53 Testing [14].

Presentation	Criteria
Familial presentation	Patient with a TP53 core tumour (breast cancer, soft-tissue sarcoma, osteosarcoma, central nervous system tumour, adrenocortical carcinoma) before 46 years AND at least one first- or second-degree relative with a core tumour before 56 years
Multiple primitive tumours	Patient with multiple tumours, including 2 TP53 core tumours, the first of which occurred before 46 years, irrespective of family history
Rare tumours	Patient with adrenocortical carcinoma, choroid plexus carcinoma, or rhabdomyosarcoma of embryonal anaplastic subtype, irrespective of family history
Very early-onset breast cancer	Breast cancer before 31 years, irrespective of family history