Figure 6.

Influence of mucin on the electrophoretic mobility of polyP; effect of polyP on binding of the S-protein receptor-binding domain (RBD) to the ACE2 receptor. (A) The PAGE analysis (7 M urea/15% polyacrylamide) of polyP (a) without or (b) with mucin. (B) Influence of polyP in the absence or presence of mucin on the interaction between the viral RBD and the cellular ACE2, as determined by the binding assay. The grey horizontal bars link the corresponding values for the inhibition by polyP in the mucin-free and in the mucin-supplemented assays. Means ± SEM (* p < 0.05).