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. 2020 Dec 22;13:3457–3465. doi: 10.2147/JPR.S281190

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© 2020 Zhang et al.

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The effects of vagus nerve stimulation (VNS) on heat and mechanical hyperalgesia in a chemotherapy-induced peripheral neuropathy (CIPN) model. CIPN was induced in rats by paclitaxel treatment on four alternative days. Rats of the VNS group underwent VNS on day 0, whereas rats of the sham group underwent mock surgery. Behavioral tests were performed on days +1 and +7 of the experiment. (A) Hindpaw withdrawal latencies during the plantar test. (B) Hindpaw withdrawal frequencies during the 15-g von Frey hair test. n = 12 per group per time point for both panels. *p<0.05 and **p<0.001.