TABLE 1:
Horse | Foot | Serotype | Promoter | Transgene | Dose | Diluent | Duration (days) |
---|---|---|---|---|---|---|---|
A | L | rAAV 2/8 | CB | nLacZ | 1.0 × 1013 | Saline | 7 |
R | rAAV 2/5 | CB | nLacZ | 1.0 × 1013 | Saline | ||
B | L | rAAV 2/8* | CMV | eGFP | 1.0 × 1013 | Saline | 7 |
R | rAAV 2/5 | CMV | eGFP | 1.0 × 1013 | Saline | ||
C | L | rAAV 2/8 | CB | nLacZ | 6.0 × 1013 | Saline | 7 |
R | rAAV 2/1 | CB | nLacZ | 6.0 × 1013 | Saline | ||
D | L | rAAV 2/8* | CMV | eGFP | 3.0 × 1013 | Saline | 21 |
R | rAAV 2/8* | CMV | eGFP | 3.0 × 1013 | Surfactant | ||
E | L | rAAV 2/8 | CB | nLacZ | 2.0 × 1013 | Saline | 7 |
R | rAAV 2/8 | CB | nLacZ | 6.0 × 1012 | Saline | ||
F | L | rAAV 2/9 | CB | nLacZ | 1.0 × 1013 | Saline | 7 |
R | rAAV 2/9 | CB | nLacZ | 1.0 × 1013 | Surfactant | ||
G | L | rAAV 2/9 | CB | nLacZ | 1.0 × 1013 | Saline | 14 |
R | rAAV 2/9 | CB | nLacZ | 1.0 × 1013 | Surfactant |
L, left; R, right.
This vector had been previously thawed and refrozen, which may have compromised its potency. Dose = viral copies (VC) injected.