Table 2.
Relation of 26 microRNAs whose expression profile in plasma is significantly different between cases with obesity and eutrophic controls.
| microRNA | Subjects with Obesity (Cases, n = 78) |
Eutrophic Individuals (Controls, n = 25) | p-Value * | q-Value ** | Model 1 (q-Value) | Model 2 (q-Value) |
|---|---|---|---|---|---|---|
| miR-103a-3p | 0.169 (0.057–0.443) | 0.567 (0.263–1.426) | 0.006 | 0.020 | 0.011 | 0.029 |
| miR-107 | 0.201 (0.067–0.520) | 0.614 (0.309–1.386) | 0.014 | 0.038 | 0.022 | 0.044 |
| miR-130a-3p | 19.321 (6.029–32.947) | 47.904 (31.421–79.317) | 0.005 | 0.004 | 0.003 | 0.009 |
| miR-130b-3p | 0.208 (0.096–0.433) | 0.442 (0.221–1.426) | 0.003 | 0.015 | 0.011 | 0.049 |
| miR-140-3p | 0.237 (0.076–0.578) | 0.872 (0.548–1.561) | 0.0001 | 0.0012 | 0.001 | 0.006 |
| miR-142-5p | 0.118 (0.036–0.214) | 0.279 (0.162–0.941) | 0.002 | 0.007 | 0.004 | 0.020 |
| miR-144-3p | 1.308 (0.276–2.872) | 6.903 (2.036–11.542) | 0.0001 | 0.0012 | 0.001 | 0.009 |
| miR-148a-3p | 0.259 (0.096–0.479) | 0.647 (0.212–1.135) | 0.006 | 0.019 | 0.010 | 0.010 |
| miR-181a-5p | 0.549 (0.229–1.107) | 1.633 (0.369–3.021) | 0.006 | 0.008 | 0.007 | 0.006 |
| miR-183-5p | 0.374 (0.244–0.649) | 0.775 (0.476–1.928) | 0.001 | 0.009 | 0.002 | 0.026 |
| miR-185-5p | 0.198 (0.083–0.480) | 0.665 (0.288–1.272) | 0.034 | 0.040 | 0.029 | 0.036 |
| miR-200c-3p | 0.540 (0.257–1.118) | 1.001 (0.454–2.161) | 0.037 | 0.044 | 0.041 | 0.039 |
| miR-205-5p | 0.163 (0.122–0.559) | 0.711 (0.319–1.322) | 0.005 | 0.020 | 0.008 | 0.031 |
| miR-21-5p | 0.257 (0.137–0.615) | 0.559 (0.261–1.238) | 0.036 | 0.041 | 0.031 | 0.032 |
| miR-210-3p | 0.110 (0.071–0.245) | 0.503 (0.117–0.672) | 0.030 | 0.048 | 0.032 | 0.010 |
| miR-221-3p | 0.212 (0.065–0.454) | 0.555 (0.268–1.549) | 0.004 | 0.013 | 0.009 | 0.010 |
| miR-222-3p | 0.311 (0.158–0.712) | 0.859 (0.470–1.396) | 0.005 | 0.019 | 0.011 | 0.009 |
| miR-15a-5p | 0.118 (0.060–0.322) | 0.356 (0.155–0.877) | 0.022 | 0.054 | 0.019 | 0.020 |
| miR-22-3p | 0.126 (0.056–0.286) | 0.320 (0.127–1.027) | 0.012 | 0.034 | 0.019 | 0.099 |
| miR-29c-3p | 0.137 (0.068–0.350) | 0.453 (0.202–1.269) | 0.007 | 0.020 | 0.009 | 0.040 |
| miR-30a-5p | 0.629 (0.294–1.347) | 1.426 (0.515–2.062) | 0.043 | 0.048 | 0.044 | 0.034 |
| miR-30c-5p | 0.274 (0.093–0.625) | 0.694 (0.235–1.462) | 0.042 | 0.050 | 0.041 | 0.054 |
| miR-33a-5p | 1.268 (0.573–2.425) | 4.54 (1.009–23.596) | 0.012 | 0.016 | 0.029 | 0.048 |
| miR-375 | 0.228 (0.124–0.609) | 0.765 (0.484–1.563) | 0.0001 | 0.002 | 0.001 | 0.009 |
| miR-424-3p | 0.892 (0.698–1.135) | 2.000 (0.834–3.127) | 0.016 | 0.030 | 0.034 | 0.076 |
| miR-486-3p | 0.301 (0.190–0.570) | 0.645 (0.238–1.326) | 0.004 | 0.009 | 0.011 | 0.040 |
Data are shown as median (25th–75th percentiles) of n-fold values. * p-values were obtained using Student t-test with the log-transformed variable. ** Raw p-values were corrected by false discovery rate (FDR; q-value). Regression analysis were done to compute a) model 1 (adjustment for age and gender) and b) model 2 (adjustment for age, gender, triglycerides and HOMA-IR). Statistical significance is shown as q-value < 0.05.