Table 4.

Impact of the clinical-demographic, nutritional and genetic factors on the critical weight loss (CWL).

Variable		Critical Weight Loss (CWL)
		No	Yes	p OR [95%CI]
Gender	Male	38 (64.41%)	21 (35.59%)	0.7888
	Female	6 (60.00%)	4 (40.00%)	1.21 [0.31–4.76]
Age (years)	≥65	18 (62.07%)	11 (37.93%)	0.8026
	<65	26 (65.00%)	14 (35.00%)	0.88 [0.33–3.38]
Tumor location	Oropharyngeal	10 (34.48%)	19 (65.52%)	0.0001 *
	Others	34 (85.00%)	6 (15.00%)	0.09 [0.03–0.29]
	Larynx	32 (88.89%)	4 (11.11%)	<0.0001 *
	Others	12 (36.36%)	21 (63.64%)	14 [4.98–49.28]
Histopathological diagnosis	Squamous-cell carcinoma	42 (65.63%)	22 (34.38%)	0.2681
	Others	2 (40.00%)	3 (60.00%)	2.86 [0.44–18.43]
T stage	T1–3	24 (66.67%)	12 (33.33%)	0.6012
	T4	20 (60.61%)	13 (39.39%)	1.30 [0.49–3.48]
N stage	N0	14 (60.87%)	9 (39.13%)	0.7233
	N1–3	30 (65.22%)	16 (34.78%)	0.83 [0.29–2.33]
M stage	M0	43 (63.25%)	25 (36.75%)	0.7325
	M1	1 (100.00%)	-	0.57 [0.02–14.49]
Disease stage	III	13 (65.00%)	7 (35.00%)	0.8918
	IVA-IVC	31 (63.26%)	18 (36.74%)	1.08 [0.36–3.20]
Performance status (PS)	≤1	37 (62.71%)	22 (37.29%)	0.6585
	>1	7 (70.00%)	3 (30.00%)	0.72 [0.17–3.08]
Alcohol consumption	Yes	19 (65.52%)	10 (34.48%)	0.7969
	No	25 (62.50%)	15 (37.50%)	1.14 [0.42–3.09]
Smoking status	Smoker	29 (56.86%)	22 (43.14%)	0.0543
	Non-smoker	15 (83.33%)	3 (16.67%)	0.26 [0.07–1.02]
Concurrent C-RT	Yes	18 (64.29%)	10 (35.71%)	0.9411
	No	26 (63.41%)	15 (36.59%)	1.04 [0.38–2.82]
NRS	<3	27 (57.45%)	20 (42.55%)	0.1163
	≥3	17 (77.27%)	5 (22.73%)	0.39 [0.12–1.26]
SGA	A	8 (53.33%)	7 (46.67%)	0.3450
	B or C	36 (66.67%)	18 (33.33%)	0.57 [0.18–1.83]
	A or B	31 (65.96%)	16 (34.04%)	0.5808
	C	13 (59.09%)	9 (40.91%)	1.34 [0.47–3.80]
ITGAM genotype	AA	21 (72.41%)	8 (27.59%)	0.2062
	GA or GG	23 (57.50%)	17 (42.50%)	1.94 [0.69–5.42]
	GG	1 (16.67%)	5 (83.33%)	0.0353 *
	GA or AA	43 (68.25%)	20 (31.75%)	0.09 [0.01–0.85]

*-statistically significant results.