Table 5.
Factors affecting overall survival.
| Factor | Log-Rank Test | |||
|---|---|---|---|---|
| Univariate Analysis | Multivariate Analysis # | |||
| HR [95%CI] | p | HR [95%CI] | p | |
| Gender (male) | 1.35 [0.58–3.11] | 0.4710 | 1.18 [0.41–3.40] | 0.7599 |
| Age (≥65 years) | 1.92 [0.99–3.71] | 0.0225 * | 1.62 [0.83–3.17] | 0.1618 |
| Smoking history (yes) | 0.69 [0.34–1.40] | 0.2290 | 0.66 [0.32–1.36] | 0.2631 |
| Smoking during treatment (yes) | 1.50 [0.28–7.91] | 0.6838 | 0.85 [0.42–1.72] | 0.6572 |
| Alcohol consumption (yes) | 0.78 [0.42–1.44] | 0.4063 | 0.79 [0.41–1.54] | 0.4972 |
| Performance status (>0) | 1.83 [0.71–4.75] | 0.1029 | 1.05 [0.39–2.80] | 0.9283 |
| Tumor location (oropharyngeal) | 1.05 [0.56–1.94] | 0.8787 | 0.98 [0.50–1.94] | 0.9587 |
| Tumor location (larynx) | 0.93 [0.51–1.70] | 0.7967 | 0.95 [0.50–1.83] | 0.8860 |
| T stage (T4) | 1.21 [0.66–2.23] | 0.5045 | 0.95 [0.48–1.86] | 0.8714 |
| N stage (N1–3) | 1.15 [0.62–2.16] | 0.6391 | 1.11 [0.54–2.26] | 0.7781 |
| M stage (M1) | 17.19 [0.01–53382.20] | 0.0001 * | 6.03 [0.52–69.64] | 0.1520 |
| TNM stage (IV) | 5.82 [0.93–36.55] | <0.0001 * | 4.14 [1.35–12.73] | 0.0135 * |
| Parenteral nutrition (yes) | 0.30 [0.06–1.36] | 0.1185 | 1.81 [0.49–6.73] | 0.3801 |
| Treatment (concurrent C-RT) | 1.00 [0.45–2.26] | 0.9905 | 1.09 [0.48–2.47] | 0.8426 |
| SGA (C) | 0.94 [0.50–1.76] | 0.8349 | 0.46 [0.21–1.02] | 0.0562 |
| SGA (BC) | 1.16 [0.56–2.43] | 0.6901 | 0.95 [0.43–2.14] | 0.9097 |
| NRS (≥3) | 1.51 [0.74–3.10] | 0.1833 | 1.74 [0.84–3.58] | 0.1355 |
| CWL (yes) | 0.94 [0.49–1.80] | 0.8539 | 0.80 [0.38–1.68] | 0.5578 |
| ITGAM genotype (AA) | 1.16 [0.61–2.19] | 0.6106 | 1.56 [0.75–3.23] | 0.2382 |
| ITGAM genotype (GG) | 3.34 [0.70–15.97] | 0.0056* | 3.01 [1.07–8.48] | 0.0376 * |
#-adjusted for statistically significant variables from univariate analysis. *-statistically significant results.