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. 2020 Dec 14;21(24):9501. doi: 10.3390/ijms21249501

Figure 2.

Figure 2

Besides inducing H3K27me3, EZH2 also methylates nonhistone proteins, either in the PRC2-dependent or PRC2-independent manner. (a) PRC2:EZH2 methylates EZH2 (automethylation) or JARID2, a PRC2 accessory cofactor, for enhancing PRC2:EZH2’s methyltransferase activity. (b) EZH2 can methylate a number of transcription factors (TFs) to either activate or repress their transcription-regulatory function. (c) In the cytosol, EZH2 interacts with Vav1 and methylates talin, thereby regulating cell adhesion and mobility. *, EZH2-methylated lysine site.