Table 2.

Summary of EZH2′s noncanonical partners in cancer.

	Cofactor	Function
Acting as coactivator	AR	EZH2 enhances AR signaling at their co-targeted genes in advanced prostate cancer [42]
	ER	Together with ERα and β-catenin, EZH2 coactivates genes coregulated by estrogen and WNT signaling in ER-positive luminal-like breast cancer cells [32]
	β-catenin	EZH2 coactivates target genes of Wnt/β-catenin signaling in mammary epithelial cells [69], ER-positive breast cancer [32] and colon cancer [71]
	NF-κB (RelA and RelB)	EZH2 promotes NF-κB signaling in the ER-negative breast cancer cells [70]
	PAF and β-Catenin	EZH2, PAF, and β-Catenin coactivates Wnt target genes in colon cancer cells [71]
	TRIM28 and subunit of the SWI/SNF complex	EZH2 co-activates a set of stemness related transcripts to promote mammosphere formation by TNBC cells [76]
	FoxM1	EZH2 co-activates genes related to tumor cell invasion, as part of HIF1a-mediated response to hypoxia [72]
Acting as corepressor	N-myc/C-myc	EZH2:PRC2 involved in Myc target gene silencing [63,64]
	ER	EZH2 co-represses the NF-κB target genes in ER-positive breast cancer cells [70]