Table 1.
N-, F- and I-BAR family domain structure and cellular functions. Adapted from [28].
| BAR Proteins | Protein Domains | Cellular Functions |
| N-BAR | ||
| Amphiphysin-1 | SH3 | Endocytosis |
| Amphiphysin-2 | - | |
| Endophilin-1, -2, -3 | SH3 | |
| F-BAR | ||
| CIP4 (CIP4, FBP17, Toca-1) |
SH3, WW | Endocytosis, Phagocytosis (FBP17), Filopodium (Toca-1), Lamellipodium (CIP4) |
| FCHO (FCHO-1, -2) |
Mu-HD | Endocytosis |
| SrGAP (SRGAP-1, -2, -3, -4) |
RhoGAP, SH3 | Filopodium |
| PACSIN (PACSIN-1, -2, -3) |
Tyr-kinase, SH3 | Endocytosis, Filopodium (PACSIN-2) |
| PSTPIP (PSTPIP-1, -2) |
SH3 | Endocytosis, Filopodium (-2), Lamellipodium (-1) |
| FCHSD (FCHSD-1, -2) |
SH3 | Endocytosis |
| FES/FER | FX, SH2 Tyr-kinase |
Lamellipodium |
| NOSTRIN | SH3 | Endocytosis |
| GAS7 | SH3, WW | Filopodium |
| I-BAR | ||
| IRSp53, IRTKS, MIM | CRIB, SH3, WH2-like motif | Endocytosis, Filopodium, Lamellipodium |
Abbreviations: BAR, Bin/Amphiphysin/Rvs; SH3, Src homoly-3; CIP4, CD42-interacting protein-4; FBP17, forming-binding protein 17; Toca-1, transactivator assembly-1; Mu-HD, Mu-homology domain; SrGAP, SLIT-ROBO Rho GTPase-activating protein; Rho-GAP, Rho GTPase-activating protein; Tyr-kinase, tyrosine-kinase; PSTPIP, proline-serine-threonine phosphatase-interacting protein; FX, F-BAR extension; SH2, Src-homology 2; CRIB, CD-42- and Rac-interactive binding.