Table 4.
N- and F-BAR proteins involved in transcytosis steps: endocytosis and trafficking.
| BAR | Function | Mechanism | Receptor | Tissue | Ref. |
| N-BAR | |||||
| Amphiphysin | Vesicle initiation and fission | CME | TfR | Fibroblasts | [64,68] |
| Endophilin | Vesicle initiation and fission | CME | - | - | [70,71] |
| Tubulo-vesicular carriers | CIE/FEME | GPCRs, TKs, IL-2 | Epithelium | [79,80] | |
| F-BAR | |||||
| CIP4, FBP17 | Vesicle initiation and fission | CME | GLUT-4 | - | [72,73] |
| Priming of FEME | CIE/FEME | ||||
| FCHO1/2 | Formation of CCPs (early stages of CME) | CME | TfR, LDLR, EGFR | Fibroblasts, neurons, astrocytes | [74,75] |
| FCHSD2 | Initiation, invagination and maturation of CCPs | CME | TfR EGFR |
[76,77,78] | |
| PACSIN-2 | Caveolae biogenesis | CIE | - | - | [81,82] |
| Tubulo-vesicular carriers | CME/CIE? | LRP1 | Brain endothelium | [7,83,84] |
Abbreviations: CME, clathrin-mediated endocytosis; CIE, clathrin-independent endocytosis; TfR, transferrin receptor; FEME, fast endophilin mediated endocytosis; GPCRs, G-protein coupled receptors; TKs, tyrosine kinase receptors; IL-2, interleukin-2; GLUT4, glucose transporter 4; CCPs, clathrin-coated pits; LDLR, low-density lipoprotein receptor; EGFR, epidermal growth factor receptor; LRP1, low-density lipoprotein receptor related protein 1.