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Epigenetic regulation of hippocampal neurons. Hippocampal neurons are regulated by histone acetylation and methylation which in turn affect long-term memory. DNA methylation regulates the development of hippocampal neurons. Abnormal changes to the levels of histone marks contribute to cognitive deficits and memory impairment. (HAT: histone acetyltransferase; ALS: amyotrophic lateral sclerosis; FTD: frontotemporal dementia).
