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. 2020 Dec 15;12(12):1213. doi: 10.3390/pharmaceutics12121213

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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LSCM images of human skin treated with F-HA histological analyses show: (a) control sample where FITC-HA was applied without microstructure treatment and remained at the surface of the skin, in comparison to the diffusion of the FITC-HA (MW = 800 kDa) into the deeper layers of excised human skin samples, in the vicinity of the microchannels created by microstructure application (b,c). (Yellow arrows indicate the diffusion of HA into deeper skin layers using MSts. Skin is auto-fluorescence (green intensity); however, the intensity of FITC-HA is higher compared to the skin background. The black and white images have background fluorescence removed and show diffusion of HA into the deeper layers of skin samples using microstructures. Scale bar = 100µm.