Table 3.

A summary of polymeric dendrimers nanocarriers loaded with anticancer drugs for breast targeting.

Polymers	Anticancer Drugs	Breast Cancer Models	Therapeutic Outcomes	References
PAMAM	Doxorubicin and cisplatin	MDA-MB-231 and MCF-7	The HA modified polymeric dendrimers showed good anticancer efficacy of when compared to the unmodified dendrimers	[73]
PAMAM	Doxorubicin	T47D and BT-549-Luc	High cellular uptake and binding.	[75]
pluronic F68- PAMAM	Doxorubicin	MCF-7/ADR	Improved antitumor activity	[76]
Collagen	Doxorubicin	MCF-7 and MDA-MB-231	Potential anticancer efficacy	[77]
PAMAM	Antisense oligodeoxynucleotides	MDA-MB-231	High cellular accumulation of the loaded drug.	[81]
polypropyleneimine	Oligodeoxynucleotide nanoparticles	MDA-MB-231	High cellular uptake	[82]
PAMAM	CpG oligodeoxynucleotide	SKBR3 and MDA-MB231	Decreased cell viability.	[83]
PAMAM	Antisense oligodeoxynucleotide	-	Growth tumor inhibition	[84]
PAMAM	Trastuzumab	MDA-MB-231and MDA-MB-453	Sustained drug release profile and reduced breast cancer cell viability.	[85]
polylysine	Trastuzumab	SKBR3 and MCF-7	High cellular internalization	[86]
PAMAM	Trastuzumab	MDA-MB-231 and SK-Br-3	Increased anticancer efficacy	[89]
PAMAM	Florescein isothiocyanated	4T1	Good cellular uptake	[90]
oligoethylene glycol	Tetrabromohydroquinone	MCF-7	Potent cytotoxicity efficacy against breast tumor.	[93]
PEG	Au nanoparticles	MCF-7	Excellent antitumor efficacy.	[94]
PAMAM	siRNA	SUM1315	High cellular uptake.	[95]
PAMAM	-	MDA-MB-231 and MCF-7	Good cytotoxicity	[97]
-	Curcumin	BT549 and SKBr3	Good anticancer activity	[98]
polylysine	PHSCN peptide	MDA-MB-231 and SUM-149	High cytotoxicity	[99]
PAMAM	Proscillaridin A and digoxin	MDA-MB-231 and MCF-7	High cell apoptosis	[101]
PAMAM	5-fluorouracil	MCF-7	Improved anticancer efficacy	[102]
PAMAM-NH2	-	MCF-7/ADR	Concentration-dependent cytotoxicity	[103]
PEG	Gemcitabine	4T1	Suppressed tumor volume	[104]
PAMAM	Tamoxifen	MCF-7	High cancer cell inhibitory effect	[105]